Sumo 2+3 [3H12] è un gene codificato dal simbolo SUMO3. È noto anche come: Small ubiquitin-related modifier 3; SUMO-3; SMT3 homolog 1; SUMO-2; Ubiquitin-like protein SMT3A; Smt3A; SUMO3; SMT3A; SMT3H1. Sumo 2+3 [3H12] ha una massa di 11.64kDa e una lunghezza di amminoacidi di 103.
Offriamo 10 anticorpi contro Sumo 2+3 [3H12], allevati nel Coniglio, che sono adatti per WB, IHC, ELISA e ICC/IF con campioni derivati da Umano, Topo e Ratto.
Informazioni su geni e proteine
Riepilogo UniProt
Ubiquitin-like protein which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process. Plays a role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Covalent attachment to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4 (PubMed:11451954, PubMed:18538659, PubMed:21965678). Plays a role in the regulation of sumoylation status of SETX (PubMed:24105744).
Sommario di Entrez
This gene encodes a member of the small ubiquitin-related modifier (SUMO) family of eukaryotic proteins. The encoded protein is covalently conjugated to other proteins via a post-translation modification known as sumoylation. Sumoylation may play a role in a wide variety of cellular processes, including nuclear transport, DNA replication and repair, mitosis, transcriptional regulation, and signal transduction. Alternatively spliced transcript variants encoding distinct proteins have been described.
Specificità del tessuto
Expressed predominantly in liver.
Somiglianze di sequenza
Belongs to the ubiquitin family. SUMO subfamily.
Modifica post-translazionale
Polymeric chains can be formed through Lys-11 cross-linking.
Posizione cellulare
Cytoplasm. Nucleus. Nucleus > PML body.
